产品描述:
S49076 is a multi-kinase inhibitor.{67829} It inhibits c-Met, Axl, Mer, FGFR1, FGFR2, and FGFR3 (IC50s = 1, 7, 2, 18, 17, and 15 nM, respectively). S49076 inhibits Axl- and c-Met-mediated Akt phosphorylation in MDA-MB-231 cells (IC50s = 33 and 50s = 50-200 nM). In vivo, S49076 (6.25-50 mg/kg) reduces mean tumor volume in GTL-16 and U87MG mouse xenograft models.