产品描述:
BVT 14225 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; IC50s = 52 and 284 nM for the human and mouse enzymes, respectively).{72442} It is selective for human 11β-HSD1 over human 11β-HSD2 (IC50 = >10,000 nM). It inhibits 11β-HSD1 by 55% in HEK293 cells expressing human HSD11B1, the gene encoding 11β-HSD1, when used at a concentration of 10 µM.{72443} BVT 14225 (50 mg/kg) reduces blood glucose levels in a rat model of diabetes induced by streptozotocin (Item No. 13104) and nicotinamide (Item No. 11127).