产品描述:
AMG 1 is an inhibitor of c-Met and Ron (IC50s = 4 and 9 nM, respectively).{66830} It is selective for c-Met and Ron over seven tyrosine and serine/threonine kinases (IC50s = 160 to 1,900 nM). AMG 1 decreases the levels of phosphorylated MET, ERK1/2, and Akt in HT-29 colon and BxPC-3 pancreatic cancer cells, as well as reduces migration in a wound-healing assay using NIH3T3/TPR-Met fibroblasts, in a concentration-dependent manner. It reduces tumor volume in a U87 glioma mouse xenograft model when administered at a dose of 30 mg/kg twice per day. AMG 1 increases bone volume and bone regrowth area in a mouse model of calvarial defect when administered at a dose of 50 µg in an absorbable collagen sponge.{66831}