产品描述:
SGC-CLK-1 is an inhibitor of CDC-like kinase 1 (Clk1) and Clk2 (IC50s = 13 and 4 nM, respectively).{66848} It is selective for Clk1 and Clk2 over Clk3, Clk4, homeodomain-interacting protein kinase 1 (HIPK1), HIPK2, and serine/threonine kinase 16 (STK16; IC50s = 363, 46, 50, 42, and 49 nM, respectively). SGC-CLK-1 (1 µM) inhibits the proliferation of MDA-MB-435 breast cancer and U-118 MG glioma cells. It induces diffuse localization of Clk2 and phosphorylated serine/arginine-rich (pSR) proteins, targets of Clks, without reducing the levels of phosphorylated SR proteins in MDA-MB-435 and U-118 MG cells when used at a concentration of 500 nM. See the Structural Genomics Consortium (SGC) website for more information.