产品描述:
BAY-826 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2; IC50 = 0.5 nM).{72444} It inhibits Tie2 autophosphorylation in human umbilical vein endothelial cells (HUVECs; EC50 = 1.3 nM).{72445} BAY-826 (0.1 or 1 µM), in combination with radiation, reduces colony formation in a colony formation assay using SMA-497, SMA-540, SMA-560, and GL261 mouse glioma cells. In vivo, BAY 826 (100 mg/kg per day), in combination with radiation, decreases tumor volume and vascularization, as well as increases the number of CD45+ T cell tumor infiltrates and animal survival in an SMA-560 murine glioma model.