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Dichloroacetate [CDA] . sodium salt
品牌： Adipogen
产品货号： AG-CR1-3684-G001
规格： 1 g

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数量： - +
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  • 产品名称:
    Dichloroacetate [CDA] . sodium salt
  • 别名:
    Dichloroacetic acid sodium salt; Bichloroacetic acid; BCA
  • 产品描述:
    Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor, consequently activating pyruvate dehydrogenase (PDH). Decreases glycolysis. Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Antitumor agent. Decreases tumor growth in vitro and in vivo. Induces mitochondrial-dependent apoptosis. Useful agent for immunometabolism research. Glucose entering the cell is metabolized by glycolysis to pyruvate. Most of the pyruvate in non-cancerous cells enters the mitochondria under aerobic conditions and a small fraction is metabolized to lactate. PDH in mitochondria converts pyruvate into acetyl-CoA, which enters the TCA cycle. In cancer cells, the oxidative (mitochondrial) pathway of glucose utilization is suppressed and most of the pyruvate is converted into lactate (Warburg effect). The relative activities of LDH and PDH therefore determine the fate of pyruvate. PDK inhibits PDH through phosphorylation and regulates its activities, resulting in suppression of the TCA cycle and mitochondrial respiration. This renders PDK a promising target for the treatment of various cancers.
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  • 保存温度:
    +4°C
  • 运输温度:
    Ambient
  • 细胞定位:
  • 预期分子量:
    127.9 . 23.0
  • 产品形式:
    solid
  • 存储溶液:
  • 有效期:
    Stable for at least 2 years after receipt when stored at -20°C.
  • 产地:
    瑞士
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    >98%
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  • CAS号:
    2156-56-1
  • 分子式:
    C2HCl2O2 . Na
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