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Amitriptyline (hydrochloride)
品牌： Cayman
产品货号： 15881-10 g
规格： 10 g

报价：
折后价：

数量： - +
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  • 产品名称:
    Amitriptyline (hydrochloride)
  • 别名:
    NIH 10794|Ro 4-1575
  • 产品描述:
    Amitriptyline is a first generation tricyclic antidepressant.{25873} It inhibits serotonin (5-HT) uptake by isolated human platelets by 39 and 68% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 77% when administered at a dose of 10 mg/kg.{61584,61585} It is also an antagonist of the 5-HT receptor subtype 5-HT2A (Ki = 20 nM), as well as histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively).{25919,25914,25803} Amitriptyline (5-25 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. 10681) or recombinant human acid sphingomyelinase.{54655} Formulations containing amitriptyline have been used in the treatment of depression and nerve pain. This product is also available as an analytical reference standard (Item Nos. 19029 | 19031).
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    313.9
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥98%
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  • CAS号:
    549-18-8
  • 分子式:
    C20H23N • HCl
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