产品描述:
Lixivaptan is a nonpeptide antagonist of vasopressin V2 receptors (Ki = 2.3 nM).{34309} It is 100-fold selective for V2 over V1a.{27294} Formulations containing lixivaptan decrease urinary excretion of aquaporin-2 in patients with chronic heart failure and increase serum sodium levels in patients with hyponatremia due to congestive heart failure.{34307,34308}