产品描述:
AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively).{13046,21749} Structurally, it is an analog of the CB1 inverse agonist rimonabant (Item No. 9000484).{21749} It has no effect on the vanilloid TRPV1 receptor.{12165} AM281 has been used to evaluate the potential effects of compounds at CB1.{13244,21496} It has also been used to study the membrane localization and cycling of CB1.{13567}