产品描述:
XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC50 = ~300-500 nM).{31192,31194} It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 µM.{31194} XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B.{31194} XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant (Item No. 10011269).{31193}