产品描述:
GSK1702934A is an activator of transient receptor potential canonical 3 (TRPC3) and TRPC6.{58569} It induces TRPC3- and TRPC6-dependent currents in whole-cell patch-clamp assays using HEK293 cells expressing the human channels (EC50s = 0.08 and 0.44 µM, respectively). GSK1702934A enhances contractility and induces arrhythmias in hearts isolated from TRPC3-overexpressing, but not wild-type, mice.{58570}