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(±)-Synephrine (hydrochloride)
品牌： Cayman
产品货号： 28398-5 g
规格： 5 g

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折后价：

数量： - +
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  • 产品名称:
    (±)-Synephrine (hydrochloride)
  • 别名:
  • 产品描述:
    (±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities.{53000,53001,53002} It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 µM, respectively).{53003} (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 µM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 µM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 µg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day.{53000,53004} It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 µg/ml.{53001} (±)-Synephrine (50 µM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 µM.{53002}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    203.7
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
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  • 纯度:
    ≥95%
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  • CAS号:
    5985-28-4
  • 分子式:
    C9H13NO2 • HCl
  • 溶解度:
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