产品描述:
Cangrelor is an ATP analog that inhibits platelet aggregation (IC50 = 0.4 nM).{40206} It is a reversible competitive antagonist of the platelet purinergic P2Y12 receptor.{23699,40207} Pretreatment with cangrelor significantly reduces blood clotting induced by ADP in a mouse model of pulmonary thromboembolism.{40208} Formulations containing cangrelor have been used to prevent blood clotting in at-risk patients.{40209}