产品描述:
Cyproterone acetate (CPA) is an androgen receptor antagonist.{27128} It binds to human androgen receptors (Ki = 14 nM) and inhibits dihydrotestosterone-induced androgen receptor activation in CV-1 cells (IC50 = 26 nM). CPA (30 mg/kg) decreases ventral prostate weight in castrated immature rats. It also suppresses accessory sexual glands and fertility in adult male rats when administered at a dose of 10 mg/kg.{27132} CPA (0.3 µM) also induces apoptosis in primary adult female rat hepatocytes.{27131} Formulations containing cyproterone acetate have been used in the treatment of androgenization in females.