产品描述:
Salvinorin B mesylate (Mesyl Sal B) is a selective κ-opioid receptor agonist that is more potent than salvinorin A (Item No. 11487) in CHO cells transfected with the human κ-opioid receptor (EC50s = 30 and 40 nM, respectively).{34566,34288} It is a mesylated version of salvinorin B (Item No. 11488) and is highly selective for κ-opioid receptors over µ- and δ-opioid receptors.{34566} In vitro, it increases dopamine uptake via the dopamine transporter (DAT) in an ERK1/2-dependent manner but does not alter expression of DAT on the cell membrane.{34567} In rats, it increases the pain threshold and blocks reinstatement of cocaine drug-seeking.