产品描述:
SKF 82958 is a dopamine D1 receptor agonist (K0.5 = 4 nM in a radioligand binding assay).{45668} It is selective for dopamine D1 over D2 receptors (K0.5 = 73 nM). SKF 82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50 = 491 nM). SKF 82958 (3 mg/kg) prevents and reverses fentanyl-induced respiratory depression, without affecting analgesia, in cats.{45669} It also increases locomotion and rearing in rats.{45670}