产品描述:
Cimetidine-d3 is intended for use as an internal standard for the quantification of cimetidine (Item No. 18743) by GC- or LC-MS. Cimetidine is a histamine H2 receptor antagonist (Ki = 0.6 μM).{30325} It also acts as an inverse agonist, inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 = 1.2 μM). Cimetidine inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 = 16 μM).{30545} In vivo, it inhibits histamine-induced gastric acid secretion in gastric fistulae and Heidenhain pouches in dogs (ED50 = 1.88 μmol/kg, p.o.). Cimetidine (20 mg/kg per day) also reduces tumor growth and neovascularization in a CMT93 colon cancer mouse syngeneic model.{47643}