产品描述:
GW 842166X is a cannabinoid 2 (CB2) receptor agonist.{14965} It increases intracellular calcium mobilization induced by the CB receptor agonist CP 55,940 (Item No. 13241) in HEK cells co-expressing a chimeric Gαq/05 protein and the human CB2 receptor (EC50 = 7.78 µM).{21542} GW 842166X is selective for CB2 over the CB1 receptor (IC50s = 0.133 and >25 µM, respectively). It inhibits LPS-induced production of inducible nitric oxide synthase (iNOS), as well as reduces LPS-induced phosphorylation of ERK1/2 in BV-2 microglia cells when used at a concentration of 100 nM.{69109} GW 842166X inhibits hyperalgesia in a rat model of inflammatory pain induced by complete Freund’s adjuvant (ED50 = 0.1 mg/kg).{14965}