产品描述:
TUG-891 is an agonist of free fatty acid receptor 4 (FFAR4/GPR120; EC50s = 0.0436 and 0.0169 µM for the human and mouse receptors, respectively).{28006} It is selective for FFAR4 over FFAR1/GPR40 (EC50 = 64.5 µM for the human receptor) and is inactive against FFAR2/GPR43 and FFAR3/GPR41. TUG-891 (1 µM) inhibits lysophosphatidic acid- or EGF-induced proliferation and migration of DU145 and PC3 prostate cancer cells.{63332} It stimulates glucagon-like peptide 1 (GLP-1) release in STC-1 enteroendrocrine cells and glucose uptake in 3T3-L1 adipocytes, as well as inhibits LPS-induced TNF-α release in RAW 264.7 macrophages when used at a concentration of 10 µM.{63333} TUG-891 (20 mg/kg) reduces sleep fragmentation-induced increases in food consumption and epididymal fat mass in mice.{63334}