产品描述:
AR-7 is a retinoic acid receptor α (RARα) antagonist.{45302} In mouse fibroblasts, AR-7 (20 μM) increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability. AR-7 is also selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively).{45303}