产品描述:
Terbutaline is a short-acting β2-adrenergic receptor (β2-AR) agonist and an active metabolite of bambuterol (Item No. 17887).{25395,45643,45644} It binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively) and selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values.{25395} Terbutaline inhibits histamine release induced by ovalbumin in isolated guinea pig lung mast cells.{45643} It also inhibits airway obstruction induced by methacholine (acetyl-β-methylcholine; Item No. 23092) or leukotriene D4 (LTD4; Item No. 20310) in anesthetized guinea pigs.{45645} Formulations containing terbutaline have been used in the treatment of asthma.