产品描述:
Methiothepin is a non-selective antagonist of the serotonin (5-HT) receptor.{39327} It is a potent antagonist of 5-HT1A and 5-HT1B (IC50 = 16 nM and Ki = 0.2 nM, respectively) as well as 5-HT2A, 5-HT2B, and 5-HT2C receptors (Kis = 3.16, 2.08, and 4.46 nM, respectively).{40435,40434,41063} Methiothepin binds to 5-HT5A, 5-HT5B, 5-HT6, and 5-HT7 receptors with Kd values of 100, 15.8, 1.8, and 1 nM, respectively.{39327} It has been used to characterize the role of serotonin in various biological processes, including renal vasodilation and gastrointestinal function.{40402,40436}