产品描述:
α-hydroxy Tamoxifen is a reactive metabolite of the estrogen receptor (ER) modulator tamoxifen (Item No. 13258) that is formed by the action of cytochrome P450 3A4 in human liver.{28206,28212} It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.{28206,28207,28208,28209,28211}