产品描述:
BMS 189961 is an agonist of retinoic acid receptor γ (RARγ; EC50 = 30 nM in a transactivation assay).{52154} It is selective for RARγ over RARβ (EC50 = 1,000 nM). In vitro, BMS 189961 decreases long bone growth and digit formation of isolated mouse embryonic limb buds when used at concentrations of 0.01 and 0.1 µM.{52155} Topical administration of BMS 189661 (40 nmol) increases the skin expression of retinoid metabolism-related genes, including Rdh10, Crabp2, and Krt4, as well as epidermal barrier genes, including Spink5, Klk5, and Klk7, in mice.{52156}