产品描述:
SC-51089 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP1 (Ki = 1.332 µM).{8322} It is selective for EP1 over EP2, EP3, and EP4 (Kis = >100, 17.5, and >100 µM, respectively), as well as the PGD2 receptor DP, PGF2α receptor FP, PGI2 receptor IP, and thromboxane A2 receptor TP (Kis = >100, 61.13, >100, and 11.18 µM, respectively). SC-51089 (10-50 µM) decreases cell death induced by amyloid-β 1-42 (Aβ42) in MC65 human neuroblastoma cells.{68326} It inhibits the growth of KMG-4 glioma cells in vitro (IC50 = ~1 µM) and reduces tumor growth in a KMG4 mouse xenograft model when administered at a dose of 25 mg/kg.{17837} SC-51089 also reduces phenylbenzoquinone-induced writhing in mice (ED50 = 6.8 mg/kg).{17835}