产品描述:
JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors.{18909} Its Ki values for the histamine H1-3 receptors exceed 1 μM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters.{18909} JNJ-777120 inhibits mast cell chemotaxis induced by 10 μM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.).{18909} It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation.{18910, 18911}