产品描述:
Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR).{36154,36155,36156} It induces relaxation of isolated tracheal muscle in guinea pigs and inhibits bronchoconstriction in a guinea pig model of experimental asthma.{36155} Administration of mabuterol decreases blood pressure and increases heart rate in a dose-dependent manner in rats, cats, and dogs.{36156} These effects are reversed by the selective β2-AR antagonist ICI 118551 (Item No. 15591), indicating mabuterol is acting at β2-ARs.{36154} At concentrations ≥1 μM, mabuterol acts as a β1-AR antagonist in isolated dog right atria.