产品描述:
Mirabegron is an agonist of the β3-adrenergic receptor (β3-AR).{28306} It induces cAMP accumulation in CHO cells expressing the β3-AR but not the β1- or β2-AR (EC50s = 0.0224, >10, and >10 µM, respectively). Mirabegron reduces contraction induced by carbamoylcholine (Item No. 14486) of isolated rat and human bladder strips (EC50s = 5.1 and 0.78 µM, respectively). It decreases the frequency of isovolumetric rhythmic bladder contractions in anesthetized rats when administered at a dose 3 mg/kg. Formulations containing mirabegron have been used in the treatment of overactive bladder.