产品描述:
Ramatroban is a dual TP and DP2/CRTH2 receptor antagonist (Kis = 4.5 and 4.3 nM for the human receptors, respectively).{12777} It is selective for these receptors over the prostaglandin E2 (PGE2) receptor subtypes EP1 and EP2, as well as the FP and IP receptors, at 1 µM.{12335} Ramatroban inhibits contractions induced by U-46619 (Item No. 16450) or PGD2 (Item No. 12010) in isolated guinea pig tracheal rings (pA2s = 8.7 and 8.6, respectively). It also reduces PGD2-induced migration of isolated human eosinophils when used at concentrations of 1, 10, and 100 nM.{11248} Ramatroban (5 mg/kg) inhibits ovalbumin-induced airway eosinophil infiltration and mucus cell hyperplasia in an ovalbumin-sensitized mouse model of asthma.{27156} Formulations containing ramatroban have been used in the treatment of allergic rhinitis.