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A-779 (trifluoroacetate salt)
品牌： Cayman
产品货号： 23396-10 mg
规格： 10 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    A-779 (trifluoroacetate salt)
  • 别名:
  • 产品描述:
    A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay).{38671} It does not compete with angiotensin 1 (AT1) and AT2 receptor agonists for binding in adrenocortical membranes when used at a concentration of 1 µM and exhibits an IC50 value greater than 10 µM in adrenomedullary membranes.{38670} In vitro, A-779 inhibits Ang (1-7)-induced release of arachidonic acid from CHO cells transfected with Mas.{38671} A-779 (0.01 mg/kg) prevents the antidiuretic effects of Ang (1-7) in water-loaded rats. It also inhibits the Ang (1-7)-induced decrease in mean arterial pressure (MAP) when administered by microinjection into the nucleus of the solitary tract with no effect on basal MAP. A-779 increases urine flow rate and sodium excretion in male, but not female, rats when AT1 and AT2 receptors are blocked by the selective antagonists losartan (Item No. 10006594) and PD 123319 (Item No. 16099), respectively.{38669}
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    873
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
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  • 纯度:
    ≥98%
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  • 分子式:
    C39H60N12O11 • XCF3COOH
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