产品描述:
Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation.{20155,20156} BMS 493 is a pan-RAR inverse agonist that blocks RARα activity with an IC50 value of 114 nM.{30013,30014} In all RAR types (RARα, RARβ, and RARγ), BMS493 prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.{30016,28461} BMS 493 has been used to elucidate the critical roles of RARs in development and immune response.{30013,30017,30012,30015}