产品描述:
Candesartan cilexetil is a prodrug form of the angiotensin II type 1 receptor (AT1) antagonist candesartan (Item No. 9003239).{42295} Candesartan cilexetil is converted to candesartan by hydrolysis in the gastrointestinal tract.{61828} It inhibits the pressor response induced by angiotensin II in normotensive rats (ID50 = 0.069 mg/kg), as well as decreases blood pressure, but not heart rate, in spontaneously hypertensive and two kidney-one clip (2K-1C) and 1K-1C renal hypertensive rats (ED25s = 0.68, 0.03, and 0.23 mg/kg, respectively).{42295,61829} Candesartan cilexetil (0.1 mg/kg) reduces stroke incidence and urinary protein excretion in stroke-prone spontaneously hypertensive rats.{61830} It prevents stress-induced tyrosine hydroxylase transcription and increases AT2 receptor expression in the ventrolateral thalamic nucleus in cold-restraint stressed spontaneously hypertensive rats when administered at a dose of 10 mg/kg per day.{18423} Formulations containing candesartan cilexetil have been used in the treatment of hypertension and heart failure.