产品描述:
Clofibrate is a selective agonist of peroxisome proliferator-activated receptor α (PPARα).{10670} In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for murine and human PPARα, respectively. It also binds to PPARγ but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.