产品描述:
Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively).{24252} Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADDs) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing.{30413} Perlapine displays >10,000-fold selectivity for hM3Dq over hM3.{30413}