产品描述:
AGN 193109-d7 is intended for use as an internal standard for the quantification of AGN 193109 (Item No. 23975) by GC- or LC-MS. AGN 193109 is an antagonist of retinoic acid receptors (RARs).{41300} AGN 193109 decreases expression of cytokeratin K5-8, 13, 14, 16, 17, and 19 genes, markers of retinoid action in ECE16-1 cells, when co-administered with TTNPB (Item No. 16144) but not when used alone. In vivo, AGN 193109 induces cleft palate or frontonasal dysplasia and eye malformations in fetuses of pregnant mice following a single oral dose of 1 mg/kg.{41301}