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Epinastine-13C-d3 (hydrobromide)
品牌： Cayman
产品货号： 30089
规格： 1 mg

报价：
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数量： - +
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  • 产品名称:
    Epinastine-13C-d3 (hydrobromide)
  • 别名:
    WAL 801CL-13C-d3
  • 产品描述:
    Epinastine-13C-d3 is intended for use as an internal standard for the quantification of epinastine (Item No. 18136) by GC- or LC-MS. Epinastine is a histamine H1 receptor antagonist (apparent Kis = 1.41 and 1.62 nM using guinea pig cerebellar and lung membranes, respectively) and mast cell stabilizer.{48871,48872} It inhibits IgE-induced histamine, TNF-α, and IL-10 secretion in human cord blood stem cell-derived mast cells (CBMCs) when used at a concentration of 0.1 μg/ml.{48872} Epinastine inhibits histamine-induced cutaneous vascular permeability in rats and bronchoconstriction in anesthetized guinea pigs (ID50s = 5 and 0.1 mg/kg, respectively).{11338} It inhibits dye leakage into the conjunctiva in a rat model of passive anaphylaxis reaction-induced vascular hyperpermeability of the conjunctiva (ID50 = 9.7 mg/kg, p.o.).{48873} Topical administration of formulations containing epinastine (0.05% three times per day) reduces lid edema, tearing, and redness, as well as the number of neutrophils and eosinophils in the lid fornix, in a mouse model of atopic conjunctivitis.{48872} Formulations containing epinastine have been used in the prevention of itching associated with allergic conjunctivitis.
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    334.2
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
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  • 纯度:
    ≥99% deuterated forms (d1-d3)
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  • 分子式:
    C15[13C]H12D3N3 • HBr
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