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Methylnaltrexone (bromide)
品牌： Cayman
产品货号： 24072-25 mg
规格： 25 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    Methylnaltrexone (bromide)
  • 别名:
    MRZ 2663BR|Naltrexone methylbromide
  • 产品描述:
    Methylnaltrexone is a quaternary positively-charged form of naltrexone (Item No. 15520) that does not cross the blood brain barrier. It is a peripherally restricted µ-opioid receptor antagonist with a Ki value of 10 nM for human recombinant receptors expressed in CHO-K1 cells and IC50 values of 130.7 and 0.43 nM in rat brain membranes prepared with sodium chloride or water, respectively.{41513} Methylnaltrexone is selective for µ-opioid receptors over δ- and κ-opioid receptors (Kis = 630.95 and 31.62 nM, respectively). It inhibits contractions evoked by electrical field stimulation (EFS) in ileum isolated from morphine-naïve guinea pigs and dose-dependently decreases spontaneous mechanical activity in ileum isolated from morphine-treated guinea pigs when administered at doses of 1 and 10 µM.{41514} It does not inhibit heroin self-administration in rats and does not induce withdrawal syndrome in morphine-dependent rhesus monkeys when administered at doses up to 32 mg/kg.{41513,41515} Formulations containing methylnaltrexone have been used in the treatment of opioid-induced constipation.
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    436.3
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
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  • 纯度:
    ≥95%
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  • CAS号:
    73232-52-7
  • 分子式:
    C21H26NO4 • Br
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