产品描述:
MSA-2 is an agonist of stimulator of interferon genes (STING).{49698} It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM, respectively) and induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2'3'-cGAMP (Item No. 19887) when used at a concentration of 30 μM. MSA-2 reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression when administered intratumorally or subcutaneously at doses of 450 μg and 50 mg/kg, respectively.{57197} It also acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.