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Pasireotide (aspartate) (trifluoroacetate salt)
品牌： Cayman
产品货号： 24092-5 mg
规格： 5 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    Pasireotide (aspartate) (trifluoroacetate salt)
  • 别名:
    SOM230
  • 产品描述:
    Pasireotide is a somatostatin receptor (SSTR) agonist that binds selectively to SST1, SST2, SST3, and SST5 over SST4 (IC50s = 9.3, 1, 1.5, 0.16, and >100 nM, respectively, for human recombinant receptors).{36543} It dose-dependently inhibits growth hormone release stimulated by growth hormone-releasing hormone (GHRH) in primary rat anterior pituitary cells and inhibits adrenocorticotropic hormone (ACTH) secretion by some primary human corticotrope adenomas at a concentration of 10 nM.{36543,36544} Pasireotide (10 nM) also inhibits ACTH release from and proliferation of mouse AtT20 pituitary corticotrope cells in vitro and inhibits tumor growth of subcutaneously implanted AtT20 cells in vivo in nude mice when administered at a dose of 1.5 μg per day.{36545} Pasireotide (0.03 mg/kg) decreases plasma ACTH concentrations and tumor size in dogs with ACTH-dependent Cushing's disease.{36546} Formulations containing pasireotide have been used in the treatment of acromegaly and Cushing's disease.
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    1313.4
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
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  • 纯度:
    ≥95%
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  • 分子式:
    C58H66N10O9 • 2C4H7NO4 • XCF3COOH
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