产品描述:
Ciprofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 0.9 µM in a transactivation assay).{61725} It is selective for PPARα over PPARγ and PPARδ at 300 µM.{7009} Ciprofibrate (250 µM) induces cell cycle arrest at the G2/M and S phases in Fao rat, but not HepG2 human, hepatocellular carcinoma cells.{61726} It decreases fasting plasma levels of triglycerides and increases fasting plasma glucose levels in the apolipoprotein CIII transgenic mouse model of hypertriglyceridemia when administered at a dose of 10 mg/kg.{29848} Formulations containing ciprofibrate have been used in the treatment of hypertriglyceridemia.