产品描述:
Ebastine-d5 is intended for use as an internal standard for the quantification of ebastine (Item No. 15372) by GC- or LC-MS. Ebastine is a histamine H1 receptor antagonist and prodrug form of carebastine (Item No. 23076).{24985} It is formed from carebastine by the cytochrome P450 (CYP) isoform CYP3A4. Ebastine binds to histamine H1 receptors with an IC50 value of 45 nM. It is selective for histamine H1 receptors over α1-adrenergic and muscarinic M1 and M2 receptors (IC50s = 183, 1,100, and >10,000 nM, respectively), as well as dopamine D2 receptors and the serotonin (5-HT) receptor subtype 5-HT1A at 1 and 10 µM, respectively.{24986} Ebastine (1, 5, and 10 µM) inhibits T cell proliferation and the production of IL-4 and IL-5 in isolated human T cells.{24987} It also reduces phytohemagglutinin-induced T cell migration and decreases LPS-induced IL-6 and TNF-α production by macrophages isolated from peripheral blood mononuclear cells (PBMCs). Ebastine inhibits histamine-induced and allergen-induced bronchospasm in guinea pigs (ED50s = 115 and 334 µg/kg, respectively).{47108} Formulations containing ebastine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.