您好，欢迎光临欣博盛生物科技商城！
服务热线：400 680 0892
购物车图片 购物车 ( )
Bisoprolol-d7 (hemifumarate)
品牌： Cayman
产品货号： 30760
规格： 1 mg

报价：
折后价：

数量： - +
问题咨询
官网链接
说明书
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
  • 产品名称:
    Bisoprolol-d7 (hemifumarate)
  • 别名:
  • 产品描述:
    Bisoprolol-d7 is intended for use as an internal standard for the quantification of bisoprolol (Item No. 23827) by GC- or LC-MS. Bisoprolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 25 nM for the human receptor).{39505} It is selective for β1- over β2-ARs (Ki = 480 nM for the human receptor in a radioligand binding assay).{39505} Bisoprolol binds to rat ventricular myocytes and heart membranes that endogenously express β1-ARs and β1- and β2-ARs, respectively (Kis = 20 and 38.1 nM, respectively).{39507} In vivo, bisoprolol (0.3 mg/kg) inhibits increases in heart rate and myocardial contractility induced by isoproterenol (Item No. 15592) in conscious dogs.{39509} It decreases blood pressure and heart rate in spontaneously hypertensive rats (SHRs) when chronically administered at a dose of 7.5 mg/kg twice per day over 19 weeks. Bisoprolol also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro; IC50 = 118.5 µg/ml) and reduces viral infectivity in SARS-CoV-2 infected Vero E6 cells (IC50 = 15.917 µg/ml).{64706} Formulations containing bisoprolol have been used in the treatment of heart failure, angina pectoris, mild to moderate hypertension, and for secondary prevention of myocardial infarction.
  • 反应种属:
  • 宿主来源:
  • 实验应用:
  • 靶标/特异性:
  • 同种型:
  • 推荐稀释度:
  • 免疫原:
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
  • 纯化方式:
  • 偶联:
  • 产品浓度:
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    390.5
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
  • 产品特点:
  • 纯度:
    ≥99% deuterated forms (d1-d7)
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
    C18H24D7NO4 • 1/2C4H4O4
  • 溶解度:
  • PubChem CID:
关注欣博盛公众号
Copyright ©2021 - 2023 深圳欣博盛生物科技有限公司
粤ICP备08007346号
  网站地图
犀牛云提供企业云服务