产品描述:
GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).{24499,14771,24500} It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract.{14857,14771} GPR35 is overexpressed in gastric cancer cells.{13309} CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki value of 12.8 nM.{24501} It less potently blocks activation of GPR35 by zaprinast (Item No. 10010421) (IC50 = 160 nM).{24498} It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM).{24498}