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Parathyroid Hormone (1-34) (human) (trifluoroacetate salt)
品牌: Cayman
产品货号: 24985
规格: 1 mg

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数量: - +
产品详情
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  • 产品名称:
    Parathyroid Hormone (1-34) (human) (trifluoroacetate salt)
  • 别名:
    LY333334|PTH (1-34)
  • 产品描述:
    Parathyroid hormone (PTH) (1-34) is an N-terminal fragment of PTH that regulates bone remodeling.{41734} It is a PTH receptor agonist that binds to the PTH1 receptor (IC50 = 2 nM) and increases cAMP accumulation (IC50 = 0.22 pM) in HEK293 cells expressing human PTH1.{41735} PTH (1-34) also stimulates cAMP accumulation in Saos-2 human osteoblast-like cells (IC50 = 0.38 nM) and bone resorption from neonatal mouse calvariae in vitro. In vivo, PTH (1-34) (40 µg/kg per day) increases bone mass in an ovariectomized adult rat model of postmenopausal osteoporosis.{41736} It also increases proteoglycan content and inhibits articular cartilage degeneration in knee joints in a mouse model of injury-induced osteoarthritis when administered at a dose of 40 µg/kg per day immediately following injury.{41737} Formulations containing PTH (1-34) have been used in the treatment of osteoporosis in men and postmenopausal women who are at high risk for fracture.
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    4117.7
  • 产品形式:
    A lyophilized powder
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • 分子式:
    C181H291N55O51S2 • XCF3COOH
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