产品描述:
NUCC-390 is a chemokine (C-X-C motif) receptor 4 (CXCR4) agonist.{61069} It induces calcium mobilization in C8161 melanoma cells expressing CXCR4 when used at a concentration of 10 µM, an effect that can be prevented by the CXCR4 antagonist AMD3100 (plerixafor; Item No. 10011332). NUCC-390 (0.0625, 0.125, and 0.25 µM) increases axon length in cultured rat spinal cord motor neurons.{61071} In vivo, NUCC-390 (26 mg/kg per day) restores gastrocnemius muscle compound muscle action potentials (CMAPs) in a mouse model of sciatic nerve crush injury. It also restores CMAPs in a mouse model of neuroparalysis induced by Papuan taipan (O. scutellatus) venom.{61070}