产品描述:
Cyclic GMP (cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. Activators of guanylate cyclases include nitric oxide and natriuretic peptides.{30357} cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis.{30357,30360,30359,30358} The degradation of cGMP to GMP is mediated by specific and non-specific phosphodiesterases.{22523,10616}