产品描述:
Losartan carboxaldehyde is an active metabolite of the angiotensin II type 1b (AT1b) receptor antagonist losartan (Item No. 10006594).{72005} It is formed from losartan by the cytochrome P450 (CYP) isoforms CYP2C9 and CYP3A4. Losartan carboxaldehyde (10 pM) inhibits platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in isolated human platelet-rich plasma.{30560} It is an agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50 = 17.1 µM in COS-7 cells expressing human PPARγ using a reporter assay).{30561} Losartan carboxaldehyde (10 µM) increases lipid accumulation, a marker of differentiation, in 3T3-L1 adipocytes.{30561} It decreases superoxide production by NADPH oxidase (NOX) in isolated human peripheral blood mononuclear cells (PBMCs) in a concentration-dependent manner.{72004} Losartan carboxaldehyde (10 µM) inhibits LPS-induced increases in COX2 mRNA expression and LPS- or angiotensin II-induced increases in supernatant prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020) levels in human umbilical vein endothelial cells (HUVECs).{30560}