产品描述:
Histamine H2 receptors mediate gastric acid secretion by coupling to Gαs proteins and increasing cAMP formation. Nizatidine is a histamine H2 receptor antagonist that decreases gastric acid secretion (ED50 = 0.9 µM in isolated gastric mucosa of bullfrog and ED50s = 1.383 and 0.08 μmol/kg in rats and dogs, respectively).{30545} Its gastroprotective activity has been exploited in clinical studies of various gastric acid disorders.{27475,27473}