产品描述:
Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).{30683,53246} It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).{30683} Domperidone (0.5-5 μg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.{53246} Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.{53247} It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).{39860} Domperidone also increases serum levels of prolactin in male rats.{46567}