产品描述:
Droperidol is a dopamine D2 and D4 receptor antagonist (Kis = 0.25 and 0.84 nM for human D2 and D4 receptors, respectively).{30677} It also inhibits the voltage-gated potassium channel hERG, also known as Kv11.1 (IC50 = 32 nM), and binds to the serotonin (5-HT) receptor subtype 5-HT2 (Ki = 1.1 nM).{30675,58006} Droperidol (1, 5, and 10 µM) decreases action potential duration in isolated canine Purkinje fibers.{65069} It prevents apomorphine-induced vomiting in dogs (ED50 = 0.0012 mg/kg) and induces catalepsy in rats (ED50 = 0.13 mg/kg).{39860} Formulations containing droperidol have been used in the treatment of surgery-associated nausea and vomiting.